Regulation of SERCA Ca pump expression by cytoplasmic [Ca] in vascular smooth muscle cells
نویسندگان
چکیده
KWAN-DUN WU, DAVID BUNGARD, AND JONATHAN LYTTON Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 100, Republic of China; Renal Division, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115; and Departments of Biochemistry and Molecular Biology and Physiology & Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
منابع مشابه
Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis
OBJECTIVES Relaxation of vascular smooth muscle (VSM) requires re-uptake of cytosolic Ca(2+) into the sarcoplasmic reticulum (SR) via the Sarco/Endoplasmic Reticulum Ca(2+) ATPase (SERCA), or extrusion via the Plasma Membrane Ca(2+) ATPase (PMCA) or sodium Ca(2+) exchanger (NCX). Peroxynitrite, a reactive species formed in vascular inflammatory diseases, upregulates SERCA activity to induce rel...
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تاریخ انتشار 2001